ChemicalBook > Product Catalog >Organic Chemistry >Organic fluorine compound >Fluorobenzonitrile series >8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile

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8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:6-(((1-(2-(azepan-1-yl)ethyl)-1h-1,2,3-triazol-4-yl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile
CAS:915365-57-0
Purity:0.99 Package:1kg
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Cot inhibitor-1
CAS:915365-57-0
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:Cot inhibitor-1
CAS:915365-57-0
Purity:98% Package:100mg, 5mg, 10mg, 2mg, 25mg, 50mg
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Products Intro: Product Name:Cot inhibitor-1
CAS:915365-57-0
Purity:98% Package:$168.9/2mg;$276.9/5mg;$444.9/10mg;$912.9/25mg;$1620.9/50mg;$2640.9/100mg;Bulk pa Remarks:98%
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Products Intro: Product Name:Cot inhibitor-1
CAS:915365-57-0
Purity:0.99 Package:100g;1kg;5KG;1KG
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Basic information
Product Name:8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
Synonyms:8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile;6-[[[1-[2-(Azepan-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-8-chloro-4-[(3-chloro-4-fluorophenyl)amino]quinoline-3-carbonitrile;Cot inhibitor-1;3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]Methyl]aMino]-;3-triazol-4-yl]methyl]amino]-;8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1;Cot inhibitor 1,Cot inhibitor1
CAS:915365-57-0
MF:C27H27Cl2FN8
MW:553.46
EINECS:
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Mol File:915365-57-0.mol
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Structure
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Chemical Properties
Boiling point 730.0±70.0 °C(Predicted)
density 1.42
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (45.17 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka8.80±0.20(Predicted)
color Light yellow to yellow
Safety Information
HS Code 2924297099
MSDS Information
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Usage And Synthesis
UsesCot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM[1].
References[1] Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8. DOI:10.1016/j.bmcl.2009.05.009
8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Preparation Products And Raw materials
Tag:8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile(915365-57-0) Related Product Information
CHLOROPHENYLSILANE Chlorobenzene Sulfenone 2-FLUOROPHENYL CYCLOPENTYL KETONE