| Company Name: |
Ascent Scientific
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4401179829988 |
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| Products Intro: |
Product Name:GR 125743
CAS:148547-33-5
Purity:>99% Package:10mg Remarks:5HT1B/1D antagonist
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GR 125743 manufacturers
- GR 125743
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- $36.00 / 1mg
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2025-11-10
- CAS:148547-33-5
- Min. Order:
- Purity: 99.76%
- Supply Ability: 10g
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| | GR 125743 Basic information |
| Product Name: | GR 125743 | | Synonyms: | GR 125743;Benzamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3-methyl-4-(4-pyridinyl)-;h5-HT1B,cognitive disorder,h5-HT1D,cardiovascular,GR-125743,GR125743,inhibit,Parkinson's disease,5-HT Receptor,GR 125743,5-hydroxytryptamine Receptor,receptor,Inhibitor,Serotonin Receptor;GR 125743, 5-HT1B/1D antagonist;GR 125743, 10 mM in DMSO | | CAS: | 148547-33-5 | | MF: | C25H28N4O2 | | MW: | 416.52 | | EINECS: | | | Product Categories: | Serotonin | | Mol File: | 148547-33-5.mol |  |
| | GR 125743 Chemical Properties |
| storage temp. | 4°C, protect from light | | solubility | DMSO: 100 mg/mL (240.08 mM) | | form | Solid | | color | White to off-white |
| | GR 125743 Usage And Synthesis |
| Uses | GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases[1][2]. | | in vivo | GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig[2].
| Animal Model: | Male Dunkin Hartley guinea-pigs (350-450 g)[2] | | Dosage: | 0.3 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Produced significant transient increases in extracellular 5-HT. |
| | IC 50 | human 5-HT1B Receptor: 8.85 (pKi); human 5-HT1D Receptor: 8.31 (pKi) | | References | [1] T Wurch, et al. Induction of a high-affinity ketanserin binding site at the 5-Hydroxytryptamine(1B) receptor by modification of its carboxy-terminal intracellular portion. Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist. Biochem Pharmacol. 2000 May 1;59(9):1117-21. DOI:10.1016/s0006-2952(99)00416-5
[2] Roberts, C., et al. The role of 5-HT1B/1D receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig. European Journal of Pharmacology. 1997 May 12;326(1):23-30. DOI:10.1016/s0014-2999(97)00156-8 |
| | GR 125743 Preparation Products And Raw materials |
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