Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

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Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester manufacturers
Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester Basic information
Product Name:Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester
Synonyms:Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester;1-Boc-1H-octahydropyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, octahydro-, 1,1-diMethylethyl ester;tert-butyl 2,3,3a,4,5,6,7,7a-octahydropyrrolo[3,2-c]pyridine-1-carboxylate;tert-butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate, Mixture of diastereomers
CAS:1147422-00-1
MF:C12H22N2O2
MW:226.32
EINECS:
Product Categories:
Mol File:1147422-00-1.mol
Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester Structure
Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
AppearanceWhite to yellow Solid-Liquid Mixture
Safety Information
MSDS Information
Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester Usage And Synthesis
Synthesis
1-Boc-1H-pyrrolo[3,2-c]pyridine

148760-75-2

Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

1147422-00-1

The general procedure for the synthesis of 1-Boc-1H-octahydropyrrolo[3,2-c]pyridine from 1-Boc-1H-pyrrolo[3,2-c]pyridine was as follows: 1H-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (2.55 g) was dissolved in a mixed solvent of ethylene glycol monomethyl ether (40 mL) and acetic acid (1 mL), and catalytic amounts of palladium hydroxide/ carbon (Pd(OH)2/C). The reaction suspension was heated at 70 °C for 24 h under hydrogen (2.0 MPa) atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to remove the solvent. The resulting residue was purified by silica gel column chromatography with the eluent being a solvent mixture of dichloromethane and methanol (10:1, v/v) to afford the final target product 1-Boc-1H-octahydropyrrolo[3,2-c]pyridine as a viscous liquid (2.64 g, 100.00% yield).

References[1] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00276
[2] Patent: US2014/228361, 2014, A1. Location in patent: Paragraph 0418-0419
Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials1-Boc-1H-pyrrolo[3,2-c]pyridine-->tert-butyl 5-benzyloctahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate-->2-Methoxyethanol-->Hydrogen-->Acetic acid
Tag:Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester(1147422-00-1) Related Product Information
1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester hydrochloride tert-butyl(3aS,7aR)-octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, octahydro-, 1,1-dimethylethyl ester, (3aR,7aS)- tert-butyl octahydropyrrolo[3,2-c]pyridine-1-carboxylate TERT-BUTYL HEXAHYDRO-1H-PYRROLO[3,2-C]PYRIDINE-5(6H)-CARBOXYLATE