| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Company Name: |
Biorbyt Ltd. |
| Tel: |
+44 (0)1223 859 353 |
| Email: |
info@biorbyt.com |
|
| | Pyridinium, 4-carbamoyl-4'-formyl-1,1'-(oxydimethylene)di-, dichloride, 4'-oxime Basic information |
| | Pyridinium, 4-carbamoyl-4'-formyl-1,1'-(oxydimethylene)di-, dichloride, 4'-oxime Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | white |
| WGK Germany | 3 | | Storage Class | 12 - Non Combustible Liquids | | Toxicity | LD50 intramuscular in mouse: 635mg/kg |
| | Pyridinium, 4-carbamoyl-4'-formyl-1,1'-(oxydimethylene)di-, dichloride, 4'-oxime Usage And Synthesis |
| Uses | Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development. |
| | Pyridinium, 4-carbamoyl-4'-formyl-1,1'-(oxydimethylene)di-, dichloride, 4'-oxime Preparation Products And Raw materials |
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