- Src Inhibitor 1
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- $34.00
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2026-07-27
- CAS:179248-59-0
- Purity: 99.68%
- Supply Ability: 10g
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| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Basic information |
| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Chemical Properties |
| Boiling point | 528.151±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.267±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | white powder | | pka | 6.753±0.30(predicted) | | color | White or off-white | | biological source | rabbit | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. | | InChI | 1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25) | | InChIKey | DMWVGXGXHPOEPT-UHFFFAOYSA-N | | SMILES | COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Usage And Synthesis |
| Description | Src-I1 (179248-59-0) is a potent and competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50‘s = 44 nM for Src and 88 nM for Lck). Src-I1 also inhibits VEGFR2 (IC50 = 320 nM). | | Uses | Src Kinase inhibitor 1
lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy | | Uses | Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies. | | Definition | ChEBI: Src Inhibitor-1 is a member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of quinazolines, a secondary amino compound, an aromatic ether and a polyether. | | General Description | A potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 μM, respectively). | | Biochem/physiol Actions | Cell permeable: yes | | storage | Desiccate at RT | | References | [1] GAOCHAO TIAN. Structural Determinants for Potent, Selective Dual Site Inhibition of Human pp60c-src by 4-Anilinoquinazolines[J]. Biochemistry Biochemistry, 2001, 40 24: 7084-7091. DOI:10.1021/bi0100586
[2] JENNY BAIN. The selectivity of protein kinase inhibitors: a further update.[J]. Biochemical Journal, 2007: 297-315. DOI:10.1042/bj20070797 |
| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Preparation Products And Raw materials |
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