| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:CHPG SodiuM salt;(RS)-2-Chloro-5-hydroxyphenylglycinesodiuMsalt
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt manufacturers
- CHPG sodium salt
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- $0.00 / 1removed
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2026-04-20
- CAS:1303993-73-8
- Min. Order:
- Purity: 100.00%
- Supply Ability: 10g
- CHPG sodium salt
-
- $0.00 / 1removed
-
2026-04-20
- CAS:1303993-73-8
- Min. Order:
- Purity: 100.00%
- Supply Ability: 10g
|
| | (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Basic information |
| | (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble to 50 mM in water and to 50 mM in DMSO | | form | Powder | | color | Brown |
| | (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Usage And Synthesis |
| Uses | CHPG Sodium Salt (cas# 1303993-73-8) is a useful research chemical.Also, it is derived from 2-Chloro-5-hydroxybenzaldehyde (C368225), which is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine. | | Biological Activity | CHPG sodium salt is a selective mGluR5 agonist and attenuates SO2-induced oxidative stress and inflammation in BV2 microglia via the TSG-6/NF-κB pathway. It prevents traumatic brain injury (TBI) in vitro and in vivo through the ERK and Akt pathways. | | in vitro | CHPG sodium salt (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO 2 derivatives treatment.
It protects BV2 cells against SO 2 -induced apoptosis.
It treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay | Cell Line: | BV2 microglial cells | | Concentration: | 10, 50, 100 and 500 μM | | Incubation Time: | 24 hours | | Result: | Increased the cell viability. | < p class="cpd-mod-vv-tit "> Apoptosis Analysis | Cell Line: | BV2 microglial cells | < /tr> | Concentration: | 0.5 mM | | Incubation Time: | 30 mins | | Result: | Protected BV2 cells against SO 2 -induced apoptosis. | Western Blot Analysis | Cell Line: | BV2 microglial cells | | Concentration: | 0.5 mM | | Incubation Time: | 30 mins | | Result: | Increased the expression of TSG-6 in both mRNA and protein levels. | | | in vivo | CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume. | Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g | | Dosage: | 250 nM < /td> | | Administration: | Injection; for 7 days | < td class="col1 fwb"> Result: | Reduced significantly cerebral lesion volume. | | | target | | | storage | +4°C (desiccate) |
| | (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Preparation Products And Raw materials |
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