2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride

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2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride manufacturers

  • SSR504734 HCl
  • SSR504734 HCl pictures
  • $41.00
  • 2026-07-15
  • CAS:615571-23-8
  • Purity: 99.93%
  • Supply Ability: 10g
2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride Basic information
Product Name:2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride
Synonyms:2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride;SSR504734;Compound 1549;SSR504734 HCl;SSR 504734 hydrochloride;2-chloro-N-((S)-phenyl((S)-piperidin-2-yl)methyl)-3-(trifluoromethyl)benzamide hydrochloride
CAS:615571-23-8
MF:C20H20ClF3N2O.HCl
MW:433
EINECS:
Product Categories:
Mol File:615571-23-8.mol
2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride Structure
2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride Chemical Properties
storage temp. 4°C, away from moisture and light
form Solid
color White to off-white
Safety Information
MSDS Information
2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride Usage And Synthesis
UsesSSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC50=18, 15, and 38nM, respectively). SSR504734 shows anti-schizophrenia, anti-anxiety and anti-depression activities[1].
in vivo

SSR504734 (i.p. and p.o.; 1-100 mg/kg; once) treatment shows good oral bioavailability[1].
SSR504734 (i.p.; 30 mg/kg; once) induces a rapid and significant decrease of specific glycine uptake[1].
SSR504734 (i.p.; 10 mg/kg; once) increases extracellular levels of Glycine in the prefrontal cortex (PFC) of freely moving rats[1].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:1-100 mg/kg
Administration:Intraperitoneal injection and oral gavage.; 1-100 mg/kg; once
Result:Showed ID50 values of 5.0 and 4.6mg/kg for i.p. and p.o. treatments, respectively.
Animal Model:Male Sprague-Dawley rats[1]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg; once
Result:Maintained at about 80% inhibition from 1 to 7h after administration.
Animal Model:Male Sprague-Dawley rats[1]
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg; once
Result:Produced a rapid and sustained increase in PFC extracellular levels of glycine.
IC 50hGlyT1: 18 nM (IC50); rGlyT1: 15 nM (IC50)
References[1] Ronan Depoortère, et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology. 2005 Nov;30(11):1963-85. DOI:10.1038/sj.npp.1300772
2-Chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride Preparation Products And Raw materials
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