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shlmai |
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021-67680335 13052188602 |
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sale1@shlmai.net |
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| | Recombinant Human Proliferating Cell Antigen Chemical Properties |
| | Recombinant Human Proliferating Cell Antigen Usage And Synthesis |
| Description | PCNA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 261 amino acids (1-261 a.a) and having a molecular mass of 28.7kDa. PCNA is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | PCNA is located in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps elevate the processivity of leading strand synthesis during DNA replication. In reaction to DNA damage, PCNA is ubiquitinated and takes part in the RAD6-dependent DNA repair pathway. 2 transcript variants encoding the same protein have been found for PCNA gene. Pseudogenes of this PCNA gene have been described on chromosome 4 and on the X chromosome. PCNA is expressed during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA is induced by UV irradiation. |
| | Recombinant Human Proliferating Cell Antigen Preparation Products And Raw materials |
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