| Company Name: |
Enzo Biochem Inc |
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
| Company Name: |
BIOSWAMP CO LTD |
| Tel: |
027-85586319 0278558631 |
| Email: |
bio-swampname@qq.com |
|
| | ARC Polyclonal Antibody Basic information |
| | ARC Polyclonal Antibody Chemical Properties |
| | ARC Polyclonal Antibody Usage And Synthesis |
| Description | Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators included RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The mRNA for ARC is expressed primarily in skeletal muscle and cardiac tissues. | | References | [1] T KOSEKI. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 9: 5156-5160. DOI: 10.1073/pnas.95.9.5156
[2] GIORGIO GAGLIA Galit L. Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.[J]. Molecular Systems Biology, 2014, 10: 753. DOI: 10.15252/msb.20145168
[3] SHEILA JEUDY. Bcl-2 inhibits the innate immune response during early pathogenesis of murine congenital muscular dystrophy.[J]. PLoS ONE, 2011: e22369. DOI: 10.1371/journal.pone.0022369 |
| | ARC Polyclonal Antibody Preparation Products And Raw materials |
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