| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 400-920-5774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:AS-605240 (potassium salt)
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:AS-605240 potassium salt
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:AS-605240 (potassium salt)
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:AS-605240 (potassium salt)
|
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| | AS-605240 (potassium salt) Basic information |
| | AS-605240 (potassium salt) Chemical Properties |
| solubility | DMF: 3 mg/ml
DMSO: 5 mg/ml
DMSO: PBS (pH 7.2) (1:10): 0.1 mg/ml |
| | AS-605240 (potassium salt) Usage And Synthesis |
| Description | AS-605240 is an orally active inhibitor of PI3-kinase γ that suppresses joint inflammation in mouse models of rheumatoid arthritis.1 It inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.1 AS-605240 inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. In vivo, AS-605240 reduced RANTES-induced peritoneal neutrophil recruitment in a mouse model of leukocyte chemotaxis with an ED50 value of 9.1 mg/kg. AS-605240 (potassium salt) has improved solubility compared to AS-605240 (Item No. 10007707).WARNING This product is not for human or veterinary use. | | References | [1] MONTSERRAT CAMPS. Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis[J]. Nature Medicine, 2005, 11 9: 936-943. DOI: 10.1038/nm1284 |
| | AS-605240 (potassium salt) Preparation Products And Raw materials |
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