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| | 2-Chloro-6-fluorobenzo[d]oxazole Basic information |
| Product Name: | 2-Chloro-6-fluorobenzo[d]oxazole | | Synonyms: | 2-Chloro-6-fluorobenzo[d]oxazole;2-Chloro-6-fluorobenzoxazole;2-Chloro-6-fluoro-benzooxazole;2-Chloro-6-fluoro-1,3-benzoxazole;Benzoxazole, 2-chloro-6-fluoro- | | CAS: | 153403-53-3 | | MF: | C7H3ClFNO | | MW: | 171.56 | | EINECS: | | | Product Categories: | | | Mol File: | 153403-53-3.mol | ![2-Chloro-6-fluorobenzo[d]oxazole Structure](CAS/GIF/153403-53-3.gif) |
| | 2-Chloro-6-fluorobenzo[d]oxazole Chemical Properties |
| Boiling point | 206.9±13.0 °C(Predicted) | | density | 1.482±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | form | fused solid | | pka | -0.83±0.30(Predicted) | | color | Dark brown |
| | 2-Chloro-6-fluorobenzo[d]oxazole Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-chloro-6-fluorobenzoxazole from 6-fluorobenzo[d]oxazole-2(3H)-thione was as follows: to a 500 mL round-bottomed flask was added 6-fluoro-2,3-dihydro-1,3-benzoxazole-2-thione (9.2 g, 54.38 mmol, 1.00 equiv.), thionyl chloride (200 mL) and N,N-dimethylformamide ( DMF, 0.5 mL). The reaction mixture was stirred in an oil bath at 80 °C for 6 hours. Upon completion of the reaction, the excess thionyl chloride was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (0/100 to 7/93) as eluent. The fraction containing the target product was collected and concentrated under reduced pressure to give 3.5 g (38% yield) of 2-chloro-6-fluorobenzoxazole as a brown oil. The product was confirmed by LC-MS (electrospray ionization, m/z) with a molecular ion peak [M+H]+ of 172. | | References | [1] Patent: WO2014/164749, 2014, A1. Location in patent: Page/Page column 257 |
| | 2-Chloro-6-fluorobenzo[d]oxazole Preparation Products And Raw materials |
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