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JTV 519 manufacturers
- JTV-519
-
- $55.00
-
2026-07-17
- CAS:1038410-88-6
- Purity: 99.88%
- Supply Ability: 10g
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| | JTV 519 Basic information |
| Product Name: | JTV 519 | | Synonyms: | 3-(4-benzylpiperidin-1-yl)-1-(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)propan-1-one:hydrochloride;JTV-519 hydrochloride;JTV-519 hydrochloride
(K201;K201, 10 mM in DMSO | | CAS: | 1038410-88-6 | | MF: | C25H33ClN2O2S | | MW: | 461.05972 | | EINECS: | | | Product Categories: | | | Mol File: | 1038410-88-6.mol |  |
| | JTV 519 Chemical Properties |
| | JTV 519 Usage And Synthesis |
| Uses | JTV-519 (K201) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2]. | | in vivo | JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment[3]. | Animal Model: | Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) [3] | | Dosage: | 0.5 mg/kg/h | | Administration: | Applied intraperitoneally 2 h before the surgery | | Result: | Improved cardiac function, where the EF and FS were significantly increased. |
| | References | [1] Darcy YL, et al. K201 (JTV519) is a Ca2+-Dependent Blocker of SERCA and a Partial Agonist of Ryanodine Receptors in Striated Muscle. Mol Pharmacol. 2016 Aug;90(2):106-15. DOI:10.1124/mol.115.102277
[2] Kaneko N, et al. Inhibition of annexin V-dependent Ca2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothiazepine derivative. Biochim Biophys Acta. 1997 Nov 13;1330(1):1-7. DOI:10.1016/s0005-2736(97)00132-6
[3] Yang J, et al. Toll-like receptor 4-induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca2+ leakage promote cardiac contractile dysfunction in sepsis. J Biol Chem. 2018 Jan 19;293(3):794-807. DOI:10.1074/jbc.M117.812289 |
| | JTV 519 Preparation Products And Raw materials |
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