6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Request For Quotation
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Suppliers list
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Email: sales@boylechem.com
Company Name: Chembest Research Laboratories Limited  
Tel: 021-20908456
Email: sales@BioChemBest.com
Company Name: WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.  
Tel: 17702719238
Email: sales@sun-shinechem.com
Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Company Name: Shanghai SynFarm Pharmaceutical Technology Co., Ltd.  
Tel: 021-50793966 18917198199
Email: info@synfarm.com

6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid manufacturers

  • CaCCinh-A01
  • CaCCinh-A01 pictures
  • $52.00
  • 2026-07-14
  • CAS:407587-33-1
  • Purity: 99.36%
  • Supply Ability: 10g
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Basic information
Product Name:6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Synonyms:6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid;CaCCinh-A01;6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid;TMEM16 BLOCKER I;CaCC(inh)-A01, TMEM16 Blocker I.;CACCINH-A01; CACC(INH)-A01, TMEM16 BLOCKER I.;Benzo[b]thiophene-3-carboxylic acid, 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-;CaCCinh-A01, 10 mM in DMSO
CAS:407587-33-1
MF:C18H21NO4S
MW:347.43
EINECS:
Product Categories:
Mol File:407587-33-1.mol
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Structure
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Chemical Properties
Boiling point 429.7±45.0 °C(Predicted)
density 1.305±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
form powder
pka4.49±0.40(Predicted)
color white to beige
InChI1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22)
InChIKeyACLUEOBQFRYTQS-UHFFFAOYSA-N
SMILES[s]1c2c(c(c1NC(=O)c3[o]ccc3)C(=O)O)CCC(C2)C(C)(C)C
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Usage And Synthesis
UsesCaCC(inh)-A01 is a potent, selective class A inhibitor of calcium-activated chloride channels (CaCCs).
Biochem/physiol ActionsCaCCinh-A01 is a TMEM16A (transmembrane member 16A) inhibitor. It also blocks anoctamin-1 (ANO1) and decreases cell viability and represses cell migration.
in vivo

CaCCinh-A01 (vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion) significantly reduces infarction when compared with MCAO-saline treatment at 24 h or 72 h in middle cerebral artery occlusion model in mice[3].

Animal Model:Two-month-old male C57/BL6J mice[3]
Dosage:5 mg/kg
Administration:Vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion
Result:Attenuated brain infarct size, improved neurological outcomes and lowered BBB permeability after ischemic stroke in mice.
storageStore at -20°C
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid Preparation Products And Raw materials
Tag:6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid(407587-33-1) Related Product Information
2-({[3-(aminocarbonyl)-4,5,6,7-tetrahydro-1-benzothien-2-yl]amino}carbonyl)benzoic acid methyl 2-(furan-2-carboxamido)-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate SALOR-INT L420239-1EA ethyl 2-(2-furoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate methyl 2-[(3-methyl-1-benzofuran-2-carbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate 2-Acetylamino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid