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| | 3-(Benzyloxy)cyclobutanol Basic information |
| Product Name: | 3-(Benzyloxy)cyclobutanol | | Synonyms: | 3-(Benzyloxy)cyclobutanol;3-(Benzyloxy)cyclobutanol 97%;Cyclobutanol, 3-(phenylmethoxy)-;3-(phenylmethoxy)cyclobutan-1-ol;3-(benzyloxy)cyclobutan-1-ol | | CAS: | 100058-61-5 | | MF: | C11H14O2 | | MW: | 178.23 | | EINECS: | | | Product Categories: | | | Mol File: | 100058-61-5.mol |  |
| | 3-(Benzyloxy)cyclobutanol Chemical Properties |
| Boiling point | 145 °C(Press: 4 Torr) | | density | 1.0773 g/cm3(Temp: 25 °C) | | storage temp. | Sealed in dry,Room Temperature | | form | liquid | | pka | 14.78±0.40(Predicted) | | color | Colourless | | InChI | InChI=1S/C11H14O2/c12-10-6-11(7-10)13-8-9-4-2-1-3-5-9/h1-5,10-12H,6-8H2 | | InChIKey | ZGSDRBWWICYJBU-UHFFFAOYSA-N | | SMILES | C1(O)CC(OCC2=CC=CC=C2)C1 |
| | 3-(Benzyloxy)cyclobutanol Usage And Synthesis |
| Synthesis | Step 1. 3-(Benzyloxy)cyclobutanone (2.00 g, 11.4 mmol), tetrahydrofuran (20 mL), and methanol (1 mL) were added to a 100 mL round-bottomed flask, and the reaction system was cooled to 0 °C. The reaction system was then cooled to 0 °C. The reaction mixture was then stirred for 30 minutes at room temperature. Subsequently, sodium borohydride (0.475 g, 12.5 mmol) was added in batches, and after addition, the reaction mixture was stirred at room temperature for 30 minutes. After completion of the reaction, the mixture was poured into water (30 mL) and extracted with ethyl acetate (2 x 30 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give 3-(benzyloxy)cyclobutanol (1.83 g, 90%) as a yellow oil.MS (ESI, cationic) m/z 179 [M + H]+. | | References | [1] Patent: WO2014/43272, 2014, A1. Location in patent: Paragraph 0298; 0304; 0305; 0306
[2] Patent: WO2018/137573, 2018, A1. Location in patent: Page/Page column 98
[3] Patent: US6579875, 2003, B1
[4] Patent: WO2015/74064, 2015, A2. Location in patent: Paragraph 0640
[5] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 7, p. 666 - 670 |
| | 3-(Benzyloxy)cyclobutanol Preparation Products And Raw materials |
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