S-EMCA manufacturers
- INT-777
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- $139.00 / 1mg
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2025-10-27
- CAS:1199796-29-6
- Min. Order:
- Purity: 99.89%
- Supply Ability: 10g
- INT-777
-
- $139.00 / 1mg
-
2025-10-24
- CAS:1199796-29-6
- Min. Order:
- Purity: 99.89%
- Supply Ability: 10g
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| Product Name: | S-EMCA | | Synonyms: | 6α-Ethyl-23(S)-Methylcholic acid;INT-777;S-EMCA;6alpha-Ethyl-23(S)-methylcholic acid;6a-Ethyl-23(S)-methylcholic acid;CS-1212;INT-777, S-EMCA;Cholane-23-carboxylic acid, 6-ethyl-3,7,12-trihydroxy-, (3α,5β,6α,7α,12α,23S)- | | CAS: | 1199796-29-6 | | MF: | C27H46O5 | | MW: | 450.65114 | | EINECS: | | | Product Categories: | | | Mol File: | 1199796-29-6.mol |  |
| | S-EMCA Chemical Properties |
| Melting point | 150-152℃ | | Boiling point | 602.8±55.0 °C(Predicted) | | density | 1.128±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:30.0(Max Conc. mg/mL);66.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);56.58(Max Conc. mM)
Ethanol:37.5(Max Conc. mg/mL);83.21(Max Conc. mM) | | pka | 4.80±0.21(Predicted) | | form | Powder | | color | White to yellow |
| | S-EMCA Usage And Synthesis |
| Uses | INT 777 is an inhibitor of TGR5 receptor, which is a transmembrane G protein-coupled receptor expressed in brown adipose tissue and muscle and activated by bile acid. | | in vivo | INT-777 (1 μM/min/kg, p.o.) has a potent choleretic effect, prevents carboxyl CoA activation and subsequent conjugation, thereby favoring its chole-hepatic shunt pathway with a ductular absorption and a potent choleretic effect in HF-fed TGR5-Tg male mice[1]. INT-777 (30 mg/kg/day, p.o.) increases energy expenditure and reduces hepatic steatosis and obesity upon high-fat feeding in TGR5-Tg mice[2]. |
| | S-EMCA Preparation Products And Raw materials |
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