2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)

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2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) manufacturers

  • PARP-2/1-IN-2
  • PARP-2/1-IN-2 pictures
  • 2026-05-11
  • CAS:912444-01-0
  • Purity:
  • Supply Ability: 10g
2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Basic information
Product Name:2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)
Synonyms:2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2);2- (2S)-2-Methylpyrrolidin-2-yl -1H-benimidazole-4- carboxamide hydrochloride (1;1H-Benzimidazole-7-carboxamide, 2-[(2S)-2-methyl-2-pyrrolidinyl]-;2-[(2S)-2-methylpyrrolidin-2-yl]-3H-benzimidazole-4-carboxamide;PARP-2/1-IN-2;(S)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride
CAS:912444-01-0
MF:C13H16N4O
MW:244.29
EINECS:
Product Categories:
Mol File:912444-01-0.mol
2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Structure
2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Chemical Properties
Safety Information
MSDS Information
2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Usage And Synthesis
UsesPARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity[1].
in vivo

PARP-2/1-IN-2 (Compound 4a) (25 or 50 mg/kg; i.p.) attenuates pain in Cisplatin (HY-17394) and Oxaliplatin (HY-17371)-induced neuropathy in mice[1].

Animal Model:Male C57BL6J mice, Cisplatin (HY-17394) and Oxaliplatin (HY-17371)-induced painful neuropathy models[1]
Dosage:25 mg/kg or 50 mg/kg
Administration:Intraperitoneal injection, two days prior to treatment with Cisplatin or oxaliplatin, with administration continuing by i.p. injection along with the Cisplatin or oxaliplatin regimen (5 days, followed by 5 days of rest, for two weekly cycles)
Result:Does not attenuate Cisplatin and Oxaliplatin-induced body weight loss. Does not Affect the decline in exploratory behavior associated with Cisplatin and Oxaliplatin Treatment. Attenuates mechanical allodynia in Cisplatin and Oxaliplatin-induced neuropathy. Attenuates thermal hyperalgesia in Cisplatin-induced neuropathy. Attenuates cold hyperalgesia associated with Oxaliplatin-induced neuropathy.
IC 50PARP2: 2 nM (Ki); PARP1: 5 nM (Ki)
References[1] Ta LE, et al. A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy. PLoS One. 2013;8(1):e54161. DOI:10.1371/journal.pone.0054161
2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2) Preparation Products And Raw materials
Tag:2-[(2S)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide hydrochloride (1:2)(912444-01-0) Related Product Information
1H-Benzimidazole, 6-chloro-7-methyl-2-[(2S)-2-methyl-2-pyrrolidinyl]-, hydrochloride (1:1) 1H-BenziMidazole-7-carboxaMide, 2-[(2S)-2-Methyl-2-pyrrolidinyl]-, hydrochloride (1:2) (R)-2-(2-Methyl-2-pyrrolidinyl)-1H-benzimidazole-4-carboxylic Acid Dihydrochloride (S)-2-(2-Methyl-2-pyrrolidinyl)-1H-benzimidazole-4-carboxylic Acid Dihydrochloride 1H-Benzimidazole, 6-chloro-7-methyl-2-[(2S)-2-methyl-2-pyrrolidinyl]- 4-Methyl-2-pyrrolidin-2-yl-1H-benzimidazole