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| | 1-Hydroxy-6-phenyl-4-trifluoroMethyl-1H-indole-2-carboxylic acid Basic information |
| Product Name: | 1-Hydroxy-6-phenyl-4-trifluoroMethyl-1H-indole-2-carboxylic acid | | Synonyms: | 1-Hydroxy-6-phenyl-4-trifluoroMethyl-1H-indole-2-carboxylic acid;1-hydroxy-4-(trifluoromethyl)-6-phenyl-1H-indole-2-carboxylic acid;KGXDBNBXAPVUIM-UHFFFAOYSA-N;LDHA-IN-1;1H-Indole-2-carboxylic acid, 1-hydroxy-6-phenyl-4-(trifluoromethyl)-;NHI-1;LDH-A Inhibitor III, NHI-1;1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylic acid, lactate dehydrogenase A inhibitor III, ldh-M inhibitor III | | CAS: | 1269802-68-7 | | MF: | C16H10F3NO3 | | MW: | 321.25 | | EINECS: | | | Product Categories: | | | Mol File: | 1269802-68-7.mol |  |
| | 1-Hydroxy-6-phenyl-4-trifluoroMethyl-1H-indole-2-carboxylic acid Chemical Properties |
| Boiling point | 556.2±60.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 100mg/mL | | pka | 2.88±0.30(Predicted) | | form | solid | | color | off-white |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 1-Hydroxy-6-phenyl-4-trifluoroMethyl-1H-indole-2-carboxylic acid Usage And Synthesis |
| Uses | A cell-permeable, non-cytotoxic N-hydroxyindole (NHI) carboxylate that acts as a potent, reversible, and isoform selective inhibitor of lactic dehydrogenase (LDH) A/LDH-1. Inhibition appears to be competitive with respect to both pyruvate (Ki = 4.7 µM) and NADH (cofactor; Ki = 8.9 µM). Acts by occupying the whole substrate pocket and part of the cofactor pocket of LDH-A. Blocks the growth of various cancer cell lines by causing an arrest at G1 phase and inducing apoptosis (IC50 = 10.8, 10.6, 11.4, and 31.5 µM for A2780/cOHP, MSTO-211H, NIH-H28, and H630 cells, respectively). Exhibits enhanced anticancer activity under hypoxic conditions (GI50 = 0.90 µM/hypoxia vs. 16.3 µM/normoxia in LPC006 cultures) and strongly synergizes with gemcitabine.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. | | Biological Activity | Cell permeable: yes', 'Primary Target
LDH-A/LDH-1', 'Target IC50: 10.8, 10.6, 11.4, and 31.5 µ |
| | 1-Hydroxy-6-phenyl-4-trifluoroMethyl-1H-indole-2-carboxylic acid Preparation Products And Raw materials |
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