4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one

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4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one Basic information
Product Name:4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one
Synonyms:4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one;2H-1-Benzopyran-2-one, 4-(chloromethyl)-5,7-dihydroxy-;4-chloromethyl-5,7-dihydroxy-chromen-2-one;DNA polymerase-IN-1
CAS:809234-33-1
MF:C10H7ClO4
MW:226.61
EINECS:
Product Categories:
Mol File:809234-33-1.mol
4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one Structure
4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one Chemical Properties
Melting point 243-245 °C(Solv: ethanol (64-17-5))
Boiling point 499.7±33.0 °C(Predicted)
density 1.569±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka7.01±0.20(Predicted)
Safety Information
MSDS Information
4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one Usage And Synthesis
UsesDNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells[1].
References[1] Bruna-Haupt EF, et al. Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents. ACS Omega. 2023 Jul 13;8(29):26479-26496. DOI:10.1021/acsomega.3c03181
4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one Preparation Products And Raw materials
Tag:4-(ChloroMethyl)-5,7-dihydroxy-2H-chroMen-2-one(809234-33-1) Related Product Information
2H-1-Benzopyran-2-one, 4-[1,1'-biphenyl]-4-yl- 7-Amino-4-chloromethylcoumarin 4-(CHLOROMETHYL)-7,8-DIHYDROCYCLOPENTA[G]CHROMEN-2(6H)-ONE 4-(1-Chloroethyl)-7-hydroxy-2H-chromen-2-one 8-CHLOROMETHYL-[1,3]DIOXOLO[4,5-G]CHROMEN-6-ONE 5,7,4''-Trimethoxy-4-phenylcoumarin