1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one

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Company Name: TargetMol Chemicals Inc.  
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Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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Company Name: Zhejiang Huida Biotech Co., Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.com

1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one manufacturers
1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Basic information
Product Name:1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one
Synonyms:BMS433771 (BMS-433771);BMS-433771 free base;BMS 433771 free base,BMS433771 free base;2H-Imidazo[4,5-c]pyridin-2-one, 1-cyclopropyl-1,3-dihydro-3-[[1-(4-hydroxybutyl)-1H-benzimidazol-2-yl]methyl]-
CAS:543700-68-1
MF:C21H23N5O2
MW:377.44
EINECS:
Product Categories:
Mol File:543700-68-1.mol
1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Structure
1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Chemical Properties
Boiling point 611.8±45.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
form Solid
pka15.11±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Usage And Synthesis
UsesBMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2].
in vivo

BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing, but has considerable pharmacodynamic differences between the two rodent models[2]
.

Animal Model:rodent models of RSV infection[2]
(cotton rat and mice)
Dosage:1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration:oral, single or bid 4 days
Result:Had prophylactic efficacy via oral dosing in both animal models.
Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.
References[1] Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother DOI:10.1093/jac/dkh558
[2] Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. DOI:10.1128/AAC.48.7.2448-2454.2004
1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Preparation Products And Raw materials
Tag:1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one(543700-68-1) Related Product Information
FUSION GLYCOPROTEIN F0/F protein, HRSV (AFX60213, SF9, HIS) GLYCOPROTEIN/G protein, HRSV (258A.A, HEK293, HIS) GLYCOPROTEIN/G protein, HRSV (95% HOMOLOGY, HEK293, HIS) FUSION GLYCOPROTEIN F0/F protein, HRSV (AHX57537, SF9, HIS) GLYCOPROTEIN/G protein, HRSV (93% HOMOLOGY, HEK293, HIS) GLYCOPROTEIN/G protein, HRSV (HEK293, HIS)