N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate

Request For Quotation
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Purity:99.77% Package:1mg;35USD|2mg;48USD|5mg;75USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Purity:>=98% Package:$35.9/1mg;$137.9/5mg;$211.9/10mg;$476.9/25mg;$853.9/50mg;$1535.9/100mg;$3455.9/2 Remarks:98%
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 13636370518
Email: shyysw007@163.com
Products Intro: Product Name:N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate
CAS:675599-62-9
Purity:>=98% Package:5mg Remarks:T80801

N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate manufacturers
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Basic information
Product Name:N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate
Synonyms:N-[(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridyl)benzamide dihydrochloride hydrate;N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate;PG01037 dihydrochloride hydrate;PG-01037 (hydrochloride);PG 01037 2HCl;PG 01037 dihydrochloride, 10 mM in DMSO
CAS:675599-62-9
MF:C26H30Cl4N4O2
MW:572.354
EINECS:
Product Categories:
Mol File:675599-62-9.mol
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Structure
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Chemical Properties
Melting point 230-232 °C(Solv: isopropanol (67-63-0))
storage temp. 2-8°C
solubility H2O: ≥8mg/mL at ~60°C
form powder
color white to tan
Safety Information
WGK Germany 3
MSDS Information
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Usage And Synthesis
DescriptionPG-01037 is a selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively). It inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM). PG-01037 (32 mg/kg) reduces progressive-ratio methamphetamine self-administration in rats allowed extended access. It reduces loss of dopaminergic neurons in the substantia nigra pars compacta and improves motor performance in the coat-hanger test in a mouse model of Parkinson''s disease induced by MPTP.
UsesPG01037 dihydrochloride is a selective D3DR antagonist.
storageDesiccate at +4°C
References[1] PETER GRUNDT. Novel Heterocyclic Trans Olefin Analogues of N-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as Selective Probes with High Affinity for the Dopamine D3 Receptor[J]. Journal of Medicinal Chemistry, 2005, 48 3: 839-848. DOI: 10.1021/jm049465g
[2] LAURA ORIO. PRECLINICAL STUDY: FULL ARTICLE: The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access[J]. Addiction Biology, 2010, 15 3: 312-323. DOI: 10.1111/j.1369-1600.2010.00211.x
[3] DANIELA ELGUETA . Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson’s disease[J]. Neuropharmacology, 2017, 113: Pages 110-123. DOI: 10.1016/j.neuropharm.2016.09.028
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Preparation Products And Raw materials
Tag:N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate(675599-62-9) Related Product Information
PROCYCLIDINE HYDROCHLORIDE SB 277011A dihydrochloride SKF 86466 HYDROCHLORIDE Atipamezole hydrochloride 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 6-HYDROXYDOPAMINE HYDROBROMIDE