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2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone manufacturers
- Retro-2 cycl
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- $40.00
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2026-07-27
- CAS:1429192-00-6
- Purity: 99.89%
- Supply Ability: 10g
- Retro-2 cycl
-
- $40.00
-
2026-07-14
- CAS:1429192-00-6
- Purity: 99.89%
- Supply Ability: 10g
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| | 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Basic information |
| Product Name: | 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone | | Synonyms: | 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone;Retro-2;Retro-2 cycl;RN 1-001;4(1H)-Quinazolinone, 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-;2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one;Retro-2 >=98% (HPLC);2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolin | | CAS: | 1429192-00-6 | | MF: | C19H16N2OS | | MW: | 320.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1429192-00-6.mol |  |
| | 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear (warmed) | | form | powder | | color | white to beige | | InChI | 1S/C19H16N2OS/c1-13-11-12-17(23-13)18-20-16-10-6-5-9-15(16)19(22)21(18)14-7-3-2-4-8-14/h2-12,18,20H,1H3 | | InChIKey | BOAPXDSRULBILC-UHFFFAOYSA-N | | SMILES | O=C1C2=CC=CC=C2NC(C3=CC=C(C)S3)N1C4=CC=CC=C4 |
| WGK Germany | 3 | | HS Code | 2934999090 | | Storage Class | 11 - Combustible Solids |
| | 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Usage And Synthesis |
| Description | Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 μM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 μM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 μM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg. | | Uses | Retro-2 is an inhibitor of Ribosome-Inactivating Proteins (RIPs) as well as a blocker of Leishmania parasitophorous vacuoles (LPV) development. | | Biochem/physiol Actions | Retro-2 is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport that selectively protect cells from ricin, cholera toxin, and Shiga-like toxins, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps. | | in vivo | Retro-2 cycl (2-50 mg/kg, once daily for 7 days) can significantly protect 90% of newborn mice from lethal EV71 challenge[3]. | Animal Model: | Newborn mice induced by EV71-WT[3] | | Dosage: | 2, 10, 50 mg/kg; daily; 7 days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Improved the survival rate of infected mice. |
| | References | [1] MATHIEU E NONNENMACHER. Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction.[J]. Journal of Virology, 2015, 89 3: 1673-1687. DOI: 10.1128/jvi.02520-14
[2] BAHNE STECHMANN. Inhibition of retrograde transport protects mice from lethal ricin challenge.[J]. Cell, 2010, 141 2: 231-242. DOI: 10.1016/j.cell.2010.01.043
[3] OLENA SHTANKO . Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection[J]. Antiviral research, 2018, 149: Pages 154-163. DOI: 10.1016/j.antiviral.2017.11.016
[4] CHRISTIAN D S NELSON. A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses.[J]. mBio, 2013: e00729-13. DOI: 10.1128/mbio.00729-13
[5] T SECHER. Retrograde Trafficking Inhibitor of Shiga Toxins Reduces Morbidity and Mortality of Mice Infected with Enterohemorrhagic Escherichia coli.[J]. Antimicrobial Agents and Chemotherapy, 2015: 5010-5013. DOI: 10.1128/aac.00455-15 |
| | 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Preparation Products And Raw materials |
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