- Sulfadimidine Sodium
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- $0.00 / 25Kg/Bag
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2026-04-23
- CAS:1981-58-4
- Min. Order: 2Kg/Bag
- Purity: 99% up, High Density
- Supply Ability: 20 tons
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| | Sulfamethazine sodium salt Basic information |
| | Sulfamethazine sodium salt Chemical Properties |
| Melting point | >288°C (dec.) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | H2O: soluble50mg/mL | | form | powder | | color | white to off-white | | Water Solubility | H2O: soluble 50mg/mL | | Merck | 14,8915 | | Stability: | Hygroscopic | | InChI | InChI=1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);; | | InChIKey | WIVZAHIZHZEEOX-UHFFFAOYSA-N | | SMILES | S(C1C=CC(N)=CC=1)(=O)(=O)NC1=NC(C)=CC(C)=N1.[NaH] | | CAS DataBase Reference | 1981-58-4 | | EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt (1981-58-4) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | WO9300000 | | TSCA | TSCA listed | | HS Code | 2933.59.8000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Sulfamethazine sodium salt Usage And Synthesis |
| Chemical Properties | White or milky white crystalline powder, odorless or almost odorless, easily soluble in water, slightly soluble in ethanol. | | Uses | Antibacterial;Inhibitor of folic acid synthesis | | Biological Activity | Sulfamethazine is an antimicrobial sulfur drug th at blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic. | | in vivo | Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1]. | Animal Model: | 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1] | | Dosage: | 80 mg/kg | | Administration: | Intravenous injection (Pharmacokinetic study) | | Result: | The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.
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| | Sulfamethazine sodium salt Preparation Products And Raw materials |
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