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Sigma-Aldrich |
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Biolab Reagents |
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027-65279366 18108604356 |
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ACROBiosystems |
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| Product Name: | MSP1T2 | | Synonyms: | Membrane Scaffold Protein 1D1;MSP1D1;MSP1T2 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![MSP1T2 Structure]() |
| | MSP1T2 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | microbial | | Water Solubility | water: soluble | | ε(extinction coefficient) | 18200M-1cm-1 at 280nm (His-tag-cleaved dissolved in 20 mM Tris pH 7.40.1M NaCl0.5mM EDTA and 0.01%NaN3)(lit.)
21000M-1cm-1 at 280nm (uncleaved His-tagged dissolved in 20 mM Tris pH 7.40.1M NaCl0.5mM EDTA and 0.01%NaN3)(lit.) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | MSP1T2 Usage And Synthesis |
| Uses | For guidelines on the use of this and other MSP′s to prepare Nanodiscs, please visit our Protocols for Membrane Scaffold Proteins and Nanodisc Formation page. | | Uses | The nanodisc system has been employed to incorporate a wide variety of proteins including GPCRs, P450s, bacteriorhodopsin, coagulation factors, cholera toxin, TAR receptor and aromatase. | | General Description | Nanodiscs are non-covalent structures that contain a phospholipid bilayer and a membrane scaffold protein (MSP), a genetically engineered protein, which mimics the function of Apolipoprotein A-1 (ApoA-1). The first MSP, MSP1, was engineered with its sequence based on the sequence of A-1, but without the globular N-terminal domain of native A-1. The Membrane Scaffold Protein 1D1 (MSP1D1) variant of MSP1 deletes the first 11 amino acids in the Helix 1 portion (referred to as “H0.5” in the accompanying figure) of the original MSP1 sequence. | | Biochem/physiol Actions | Membrane scaffold protein 1D1 (MSP1D1) is derived from apolipoprotein A-I. It is an amphipathic synthetic protein, which self assembles to form nanodiscs. |
| | MSP1T2 Preparation Products And Raw materials |
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