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| | si:ch211-195o19.1 Basic information |
| Product Name: | si:ch211-195o19.1 | | Synonyms: | Anti-angptl1 antibody produced in rabbit;si:ch211-195o19.1;angptl1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![si:ch211-195o19.1 Structure]() |
| | si:ch211-195o19.1 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution | | biological source | rabbit |
| WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | si:ch211-195o19.1 Usage And Synthesis |
| Biological Activity | ANGPTL1 (angiopoietin like 1) is a potent angiogenesis regulator. Its expression is negatively related with lymph node metastasis, invasion and poor prognosis. It acts as a tumor suppressor in breast and lung cancer cells. It suppresses SLUG (Snail homolog)-dependent EMT (epithelial mesenchymal transition) in lung cancer, thus, preventing cell motility. It is also thought to function as a transcription repressor. It forms heterodimers with Ear2 (V-erbA-related protein 2), and they may constitute a distinct orphan receptor signaling. It also functions as an agonist of Tie2, which is an endothelial receptor tyrosine kinase. |
| | si:ch211-195o19.1 Preparation Products And Raw materials |
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