|
|
| Product Name: | TIMD1 | | Synonyms: | Mouse Interleukin 35 elisa kit;KIM1;T-cell immunoglobulin and mucin domain-containing protein 4;Tim-1 (human): FC (human);IL-35 (mouse): FC (human);Interleukin-35;Hepatitis A virus cellular receptor 1;T-cell immunoglobulin and mucin domain-containing protein 1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | Elisa Kit-Mouse Elisa Kit | | Mol File: | Mol File | ![TIMD1 Structure]() |
| | TIMD1 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | white | | biological source | human
mouse |
| WGK Germany | WGK 2 | | Storage Class | 10 - Combustible liquids |
| | TIMD1 Usage And Synthesis |
| Uses | IL-35 has been used to study its immunosuppressive effect on acute graft-versus-host disease in a mouse model.Ithas also been used to study its effects on the differentiation of granulocytemacrophage-colony-stimulating factor-producing T helper cells (ThGM). IL-35has been used to study its effects on bleomycin-induced pulmonary fibrosis. | | Biological Activity | Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule th at mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cellsμ ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy.IL-35 is produced inresponse to agonists of toll-like receptors 3 and 4 (TLR 3 & 4) and interferon γ (IFN-γ). It is secreted mainly by activated B cells, CD4+ Foxp3+ regulatoryT cells (Tregs), and at a lower concentration by monocytes, smooth muscle cells, and endothelial cells. |
| | TIMD1 Preparation Products And Raw materials |
|