| Company Name: |
Biolab Reagents |
| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
| Company Name: |
ACROBiosystems |
| Tel: |
13121935750 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
| Company Name: |
Elabscience |
| Tel: |
15608650971 |
| Email: |
1092989564@qq.com |
|
| | CATHEPSIN S Basic information |
| Product Name: | CATHEPSIN S | | Synonyms: | CTSS;FLJ50259;MGC3886;Cathepsin S Active human;CATHEPSIN S;CATHEPSIN S, BOVINE SPLEEN;EC 3.4.22.27;Cathepsin S from Human, recombinant | | CAS: | 71965-46-3 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CATHEPSIN S Structure]() |
| | CATHEPSIN S Chemical Properties |
| storage temp. | -70°C | | form | aqueous solution | | color | White to off-white | | biological source | human | | Specific Activity | ≥8100pmol/min-μg | | Major Application | life science and biopharma |
| WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Eye Irrit. 2
Repr. 1B
Skin Irrit. 2 |
| | CATHEPSIN S Usage And Synthesis |
| Uses | Active human cathepsin S is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human cathepsin S has been used in a study to assess the pathogenesis of Alzheimer′s disease. Active human cathepsin S has also been used in a study to investigate the optimization of selectivity of Azepanone-based inhibitors. | | General Description | Human cathepsin S (GenBank Accession No. NM_004079.3), CD33 signal peptide(amino acids 1-16) + cathepsin S (amino acids 17-331), with C-terminal HIS tag, MW = 37 kDa, expressed in FreeStyle 293-F cells. | | Biological Activity | Cathepsin S, as a lysosomal protease, facilitates the breakdown of unwanted and damaged proteins in the endo-lysosomal pathway. Moreover, it plays specific roles, such as contributing to major histocompatibility complex (MHC) class II antigen presentation by aiding in the degradation of the invariant chain. Dysregulation of cathepsin S has been associated with various pathological conditions, such as cancer, arthritis, and cardiovascular disease. Cathepsin S is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It is also used as a biomarker for atherosclerosis, diabetes, adiposity, and atherogenesis. Moreover, it acts as a promising target against brain-penetrating and for the treatment of multiple sclerosis and neuropathic pain. |
| | CATHEPSIN S Preparation Products And Raw materials |
|