FRAX1036
| 中文名称 | FRAX1036 |
|---|---|
| 中文同义词 | PAK小分子抑制剂(FRAX1036);FRAX1036游离态;化合物FRAX1036;6-(2-氯-4-(6-甲基吡嗪-2-基)苯基)-8-乙基-2-((2-(1-甲基哌啶-4-基)乙基)氨基)吡啶并[2,3-D]嘧啶-7(8H)-酮;化合物FRAX1036,10 MM DMSO 溶液;FRAX-1036 (FRAX1036;FRAX 1036) |
| 英文名称 | FRAX1036 |
| 英文同义词 | FRAX1036;FRAX1036 (Free base);FRAX-1036;FRAX 1036;CS-2271;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-;6-(2-Chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;FRAX 1036,Inhibitor,p21 activated kinases,PAK,FRAX1036,inhibit,FRAX-1036;6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one |
| CAS号 | 1432908-05-8 |
| 分子式 | C28H32ClN7O |
| 分子量 | 518.05 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;抑制剂 |
| Mol文件 | 1432908-05-8.mol |
| 结构式 |  |
FRAX1036 性质
| 沸点 | 669.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1?+-.0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 9.46±0.10(Predicted) |
| 颜色 | 白色至浅黄色 |
|
PAK1 23.3 nM (Ki) |
PAK2 72.4 nM (Ki) |
PAK4 2.4 μM (Ki) |
FRAX1036 is a PAK inhibitor with K i s of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively. FRAX1036 (2.5 μM) incombination with docetaxel alters stathmin phosphorylation, induces the apoptotic marker cleaved PARP and increases kinetics of apoptosis in MDA-MB-175 and HCC2911 cells; also alters microtubule organization, mitosis and cell fate in U2OS cells. Moreover, FRAX1036 shows significantly effective inhibition on U2OS cells. FRAX1036 (10 μM) affects the proliferation of non-small cell lung cancer (NSCLC) cells when added to KRAS prenylation inhibitors.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-19538 | FRAX1036 FRAX1036 | 1432908-05-8 | 1mg | 600元 |
| 2025/12/22 | HY-19538 | FRAX1036 FRAX1036 | 1432908-05-8 | 5mg | 1100元 |