1881233-39-1
| 中文名称 | 1881233-39-1 |
|---|---|
| 中文同义词 | 化合物PI4KIIIBETA-IN-10;N-(5-(3-(N-(4-羟基苯基)氨磺酰基)-4-甲氧基苯基)-4-甲基噻唑-2-基)新戊酰胺;化合物PI4KIIIBETA-IN-10,10 MM DMSO 溶液;CAS:1881233-39-1;PI4KIIIbeta-IN-10 (N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)pivalamide) |
| 英文名称 | PI4KIII beta inhibitor 1 |
| 英文同义词 | PI4KIII beta inhibitor 1;PI4KIIIbeta-IN-10;N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide;N-(5-(3-(N-(4-HYDROXYPHENYL)SULFAMOYL)-4-METHOXYPHENYL)-4-METHYLTHIAZOL-2-YL)PIVALAMIDE;Propanamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]-2,2-dimethyl-;PI4KIII beta inhibitor 10;inhibit,Phosphatidylinositol 4 kinases,Inhibitor,PI4 kinases,PI4K,PI4KIIIbetaIN10,PI-4KIIIbeta-IN-10,PI4KIIIbeta IN 10;PI4KIIIbeta-IN-10, 10 mM in DMSO |
| CAS号 | 1881233-39-1 |
| 分子式 | C22H25N3O5S2 |
| 分子量 | 475.58 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1881233-39-1.mol |
| 结构式 |  |
1881233-39-1 性质
| 密度 | 1.367±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥30 mg/ml（63.08mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.06±0.10(Predicted) |
| 颜色 | 白色至米白色 |
|
PI4KIIIβ 3.6 nM (IC 50 ) |
PI4KIIIα 3 μM (IC 50 ) |
PI3Kδ 720 nM (IC 50 ) |
PI3KC2γ 1 μM (IC 50 ) |
PI3Kα 10 μM (IC 50 ) |
PI3Kγ 20 μM (IC 50 ) |
PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC 50 ~1 µM), PI3Kα (~10 µM), and PI4KIIIα (~3 µM), and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-100198 | 1881233-39-1 PI4KIIIbeta-IN-10 | 1881233-39-1 | 1mg | 746元 |
| 2025/12/22 | HY-100198 | 1881233-39-1 PI4KIIIbeta-IN-10 | 1881233-39-1 | 5mg | 1775元 |