| Company Name: |
BePharm Ltd |
| Tel: |
400-685-9117 |
| Email: |
market@bepharm.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
|
| | 1-(2-Methoxypyrimidin-5-yl)ethanone Basic information |
| | 1-(2-Methoxypyrimidin-5-yl)ethanone Chemical Properties |
| Boiling point | 280.0±32.0 °C(Predicted) | | density | 1.157±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -0.67±0.22(Predicted) |
| | 1-(2-Methoxypyrimidin-5-yl)ethanone Usage And Synthesis |
| Synthesis | GENERAL METHODS: 2-methoxypyrimidine (1c, 0.216 mg, 2 mmol) was mixed with acetyl chloride (2a, 0.157 mg, 2 mmol), and CTAB or CTAC (0.001 mol) was added as a catalyst and dissolved in dichloroethane. The reaction mixture was heated in a microwave synthesizer (Biotage Initiator+ SP Wave model, power 0.200 W, frequency 2.45 GHz, capped at 60 W at steady state) for 5 min, and the reaction conditions were controlled to be at 100 °C and 2 bar pressure. Upon completion of the reaction, the target product 1-(2-methoxypyrimidin-5-yl)ethanone (3o) was isolated and purified by column chromatography using silica gel as stationary phase and mixed solvent of ethyl acetate-petroleum ether as eluent. | | References | [1] Tetrahedron Letters, 2013, vol. 54, # 26, p. 3431 - 3436 |
| | 1-(2-Methoxypyrimidin-5-yl)ethanone Preparation Products And Raw materials |
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