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| | GSK 461364 analogue I Basic information |
| Product Name: | GSK 461364 analogue I | | Synonyms: | GSK 461364 analogue I;GSK579289A;2-Thiophenecarboxamide, 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[6-[(1-methyl-4-piperidinyl)oxy]-1H-benzimidazol-1-yl]- | | CAS: | 929095-23-8 | | MF: | C26H27ClN4O3S | | MW: | 511.04 | | EINECS: | | | Product Categories: | | | Mol File: | 929095-23-8.mol |  |
| | GSK 461364 analogue I Chemical Properties |
| Boiling point | 678.2±65.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: 25 mg/ml | | form | A solid | | pka | 15.07±0.50(Predicted) |
| | GSK 461364 analogue I Usage And Synthesis |
| Biological Activity | GSK579289A is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).1 It is selective for Plk1 over Plk3 (IC50 = 630 nM). GSK579289A inhibits proliferation of HCT116 cells (IC50 = 11 nM). | | References | 1.Rheault, T.R., Donaldson, K.H., Badiang-Alberti, J.G., et al.Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like propertiesBioorg. Med. Chem. Lett.20(15)4587-4592(2010) |
| | GSK 461364 analogue I Preparation Products And Raw materials |
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