| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
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Product Name:UWA-101 (hydrochloride)
CAS:1431520-52-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:UWA-101 hydrochloride
CAS:1431520-52-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:UWA-101 hydrochloride
CAS:1431520-52-3
Package:50mg/RMB 18900
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:UWA-101 (hydrochloride)
CAS:1431520-52-3
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| | UWA-101 (hydrochloride) Basic information |
| Product Name: | UWA-101 (hydrochloride) | | Synonyms: | UWA-101 (hydrochloride);eMolecules ID: 68868466;α-cyclopropyl-N-methyl-1,3-benzodioxole-5-ethanamine,monohydrochloride;UWA-101 hydrochloride in methanol | | CAS: | 1431520-52-3 | | MF: | C13H18ClNO2 | | MW: | 255.741 | | EINECS: | | | Product Categories: | | | Mol File: | 1431520-52-3.mol |  |
| | UWA-101 (hydrochloride) Chemical Properties |
| | UWA-101 (hydrochloride) Usage And Synthesis |
| Description | UWA-101 (hydrochloride) is an analytical reference material that is structurally categorized as an amphetamine. It inhibits both serotonin and dopamine reuptake (Kis = 467 and 894 nM, respectively), but has no effect on the reuptake of noradrenaline (Ki > 50,000 nM).1 UWA-101 enhances L-DOPA anti-parkinsonian action without exacerbating dyskinesia.2 This product is intended for research and forensic applications. | | Uses | UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 μM and 2.3 μM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease[1][2]. | | in vivo | UWA-101 hydrochloride (3 mg/kg; i.p.; single) reduces L-DOPA-induced dyskinesia in Parkinson's disease rat model[1]. | Animal Model: | Male Sprague-Dawley rats (250-300 g; Parkinson's disease model)[1]. | | Dosage: | 3 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Reduced L-DOPA-induced vertical activity by 60%. |
| | References | 1. Johnston, T.H., Millar, Z., Huot, P., et al. A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates FASEB J. 26(5),2154-2163(2012).
2. Huot, P., Johnston, T.H., Gandy, M.N., et al. The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset PLoS One 7(9),(2012). |
| | UWA-101 (hydrochloride) Preparation Products And Raw materials |
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