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BOC Sciences |
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TCS-3035 manufacturers
- TCS 3035
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- $2560.00
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2026-01-05
- CAS:871085-49-3
- Purity:
- Supply Ability: 10g
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| | TCS-3035 Basic information |
| Product Name: | TCS-3035 | | Synonyms: | TCS-3035;(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;2-[4-[(Z)-(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxyacetic acid;Acetic acid, 2-[4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]phenoxy]- | | CAS: | 871085-49-3 | | MF: | C12H9NO5S | | MW: | 279.27 | | EINECS: | | | Product Categories: | | | Mol File: | 871085-49-3.mol |  |
| | TCS-3035 Chemical Properties |
| density | 1.550±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | <27.93mg/ml in DMSO | | form | solid | | pka | 3.02±0.10(Predicted) | | color | Off White |
| | TCS-3035 Usage And Synthesis |
| Uses | TCS 3035 is a potent and selective GPR35 agonist. | | Biological Activity | tcs3035, a gpr35 agonist, shows significantly high potency at rat and human gpr35 orthologs with pec50 values of 5.13 and 5.86, respectively [1]. g protein-coupled receptors (gpcrs) are the largest and most studied group of transmembrane polypeptides. gpr35 is a poorly characterized g protein-coupled receptor that plays an important role in immune-modulation, gastric function and the regulation of insulin secretion. gpr35 is predominantly expressed in the gastro-intestinal tract and immune tissues. the tryptophan metabolite kynurenic acid has been suggested to be the endogenous ligand for gpr35 [1]. | | in vitro | mutation to alanine of the conserved arginine at position 3.36 in either flag-hgpr35-eyfp or flag-rgpr35-eyfp resulted in a complete loss of agonist function of tcs3035 [1]. in addition, tcs3035-induced internalization of gpr35 is correlated with tcs3035 potency in receptor-β-arrestin-2 interaction bret assays. mutation to alanine of tyrosine 3.32 in transmembrane domain iii abolished β-arrestin-2 recruitment in response to tcs3035 [1]. | | target | gpr35 | | storage | Store at +4°C | | references | 1. jenkins l, alvarez-curto e, campbell k, de munnik s, canals m, schlyer s, et al. agonist activation of the g protein-coupled receptor gpr35 involves transmembrane domain iii and is transduced via galpha(1)(3) and beta-arrestin-2. br j pharmacol. 2011;162(3):733-48. |
| | TCS-3035 Preparation Products And Raw materials |
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