- 2,4-Difluorophenol
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- $0.00 / 1KG
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2026-03-20
- CAS:367-27-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 mt
- 2,4-Difluorophenol
-
- $9.00 / 1KG
-
2025-09-25
- CAS:367-27-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 2,4-Difluorophenol
-
- $1.00 / 1KG
-
2024-06-18
- CAS:367-27-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20t
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| | 2,4-Difluorophenol Basic information |
| Product Name: | 2,4-Difluorophenol | | Synonyms: | 2,4-Difluorophenol 98%;4-Difluorophenol;2,4- twodifluoro phenol;2,4-Difluorophenol 98%, 4-Difluorophenol 98%;2,4-DIFLUOROPHENOL;Phenol, 2,4-difluoro-;2,4-Difluorophenol, 98+%;2,4-Difluorophenol, 99+% | | CAS: | 367-27-1 | | MF: | C6H4F2O | | MW: | 130.09 | | EINECS: | 206-688-0 | | Product Categories: | Organic Building Blocks;Oxygen Compounds;Phenols;Fluoro-Aromatics;Aromatic Phenols;Fluorobenzene;Phenol&Thiophenol&Mercaptan;Fluorophenols;Heterocyclic Acids,Quinolines | | Mol File: | 367-27-1.mol |  |
| | 2,4-Difluorophenol Chemical Properties |
| Melting point | 22.4 °C (lit.) | | Boiling point | 52-53 °C/19 mmHg (lit.) | | density | 1.362 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.486(lit.) | | Fp | 134 °F | | storage temp. | Inert atmosphere,Room Temperature | | pka | 8.72±0.18(Predicted) | | form | powder to lump to clear liquid | | color | White or Colorless to Yellow | | Specific Gravity | 1.362 | | Water Solubility | slightly soluble | | BRN | 1934803 | | InChI | 1S/C6H4F2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H | | InChIKey | NVWVWEWVLBKPSM-UHFFFAOYSA-N | | SMILES | Oc1ccc(F)cc1F | | CAS DataBase Reference | 367-27-1(CAS DataBase Reference) | | NIST Chemistry Reference | 2,4-Difluorophenol(367-27-1) |
| Hazard Codes | Xn,Xi,C,F | | Risk Statements | 20/21/22-37/38-41-34-11-36/37/38 | | Safety Statements | 26-36/37/39-45-16 | | RIDADR | 1992 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29081000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2,4-Difluorophenol Usage And Synthesis |
| Chemical Properties | clear yellow-green liquid after melting | | Uses | 2,4-Difluorophenol, is an organic building block used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. It is also used in the synthesis of new α-Phenoxyacetamide derivatives, acting as type III secretion system of Pseudomonas aeruginosa PAO1, a gram-negative bacteria. | | Uses | 2,4-Difluorophenol has been used:
- as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine
- in the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye
| | Synthesis | General procedure for the synthesis of 2,4-difluorophenol from 2,4-difluorophenylboronic acid: arylboronic acid (1 mmol), 30% aqueous H2O2 solution (0.2 mL), ZnO nanocatalyst (5 mol%, sample ZnO-1), and 2 mL of water were stirred and mixed in a 50 mL round-bottomed flask at room temperature and under aerobic conditions. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with 20 mL of water and extracted with ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over Na2SO4. The solvent was removed by rotary evaporator under reduced pressure. The crude product was purified by silica gel (100-200 mesh) column chromatography (hexane/ethyl acetate, 9:1) to afford the target product 2,4-difluorophenol. The product structure was confirmed by 1H NMR and 13C NMR. | | References | [1] Applied Catalysis A: General, 2018, vol. 562, p. 58 - 66
[2] Tetrahedron Letters, 2015, vol. 56, # 14, p. 1780 - 1783
[3] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 633 - 634 |
| | 2,4-Difluorophenol Preparation Products And Raw materials |
| Raw materials | 2,4-Dichloronitrobenzene-->2,5-Difluorophenol-->Phenol-->2,4-Difluorophenylboronic acid-->Water-->Hydrogen peroxide-->1,4-Difluorobenzene | | Preparation Products | 3-(2,4-difluorophenoxy)propanoic acid-->3-AMINO-2-(2,4-DIFLUOROPHENOXY)PYRIDINE-->2,4-DIFLUORO-6-NITROPHENOL-->2,4-Difluoro-5-nitrophenol-->2-Bromo-4,6-difluorophenol-->ABBV-075-->4-Fluorophenol-->AKOS B013914-->3-Ethoxy-2,6-difluorobenzaldehyde-->2-(2,4-difluorophenoxy)aniline-->4'-(2,4-DIFLUOROPHENOXY)ACETOPHENONE-->7,9-difluoro-2,3,4,5-tetrahydro-1-benzoxepin-5-one |
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