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| | Ribitol,2,5-anhydro-1-deoxy-3,4-O-isopropylidene-1-(1-nitrosoureido)-, DL- (8CI) Basic information |
| | Ribitol,2,5-anhydro-1-deoxy-3,4-O-isopropylidene-1-(1-nitrosoureido)-, DL- (8CI) Chemical Properties |
| Boiling point | 363.5±45.0 °C(Predicted) | | density | 1.62±0.1 g/cm3(Predicted) | | pka | 12.15±0.50(Predicted) |
| | Ribitol,2,5-anhydro-1-deoxy-3,4-O-isopropylidene-1-(1-nitrosoureido)-, DL- (8CI) Usage And Synthesis |
| Description | Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 signaling, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins. | | Uses | Azadirone sensitized cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 expression, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins (Bid). Azadirone has antiplasmodial activity[1][2]. | | References | [1] Gupta SC, et al. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. J Biol Chem. 2013 Nov 8;288(45):32343-32356. DOI:10.1074/jbc.M113.455188
[2] Chianese G, et al. Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica. J Nat Prod. 2010 Aug 27;73(8):1448-52. DOI:10.1021/np100325q |
| | Ribitol,2,5-anhydro-1-deoxy-3,4-O-isopropylidene-1-(1-nitrosoureido)-, DL- (8CI) Preparation Products And Raw materials |
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