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Wuhan Chemwish Technology Co., Ltd
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Product Name:Ethyl1-Methyl-5-nitroiMidazole-2-carboxylate
CAS:1564-49-4
Purity:98% Package:1g;5g;25g;50g;100g;500g
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| | ETHYL 1-METHYL-5-NITROIMIDAZOLE-2-CARBOXYLATE Basic information |
| Product Name: | ETHYL 1-METHYL-5-NITROIMIDAZOLE-2-CARBOXYLATE | | Synonyms: | ETHYL 1-METHYL-5-NITROIMIDAZOLE-2-CARBOXYLATE;AKOS 92999;Ethyl 1-Methyl-5-nitro-1H-iMidazole-2-carboxylate;1H-Imidazole-2-carboxylic acid, 1-methyl-5-nitro-, ethyl ester;ethyl 1-methyl-5-nitro-imidazole-2-carboxylate - [E83254] | | CAS: | 1564-49-4 | | MF: | C7H9N3O4 | | MW: | 199.16 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | ETHYL 1-METHYL-5-NITROIMIDAZOLE-2-CARBOXYLATE Chemical Properties |
| Melting point | 81-83°C | | Boiling point | 350.7±34.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -0.95±0.25(Predicted) | | Appearance | White to off-white Solid |
| | ETHYL 1-METHYL-5-NITROIMIDAZOLE-2-CARBOXYLATE Usage And Synthesis |
| Synthesis | Step 6a. ethyl 1-methyl-1H-imidazole-2-carboxylate (2.0 g, 13 mmol) was dissolved in 8 mL of concentrated H2SO4, followed by the slow addition of 8 mL of concentrated HNO3. The reaction mixture was stirred at 70 °C for 3 h. The reaction mixture was then extracted with dichloromethane (DCM). After completion of the reaction, the solution was diluted with H2O and the pH was adjusted to 7-8 with aqueous Na2CO3. The reaction mixture was extracted with dichloromethane (DCM) and the organic layers were combined and concentrated. Purification by silica gel column chromatography (eluent: ethyl acetate/petroleum ether) afforded the target compound 1-methyl-5-nitro-1H-imidazole-2-carboxylic acid ethyl ester as a yellow solid (0.9 g, 34.7% yield).ESI-MS m/z = 200.20 [M + H]+. | | References | [1] Patent: WO2016/183266, 2016, A1. Location in patent: Page/Page column 50 |
| | ETHYL 1-METHYL-5-NITROIMIDAZOLE-2-CARBOXYLATE Preparation Products And Raw materials |
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