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| | HS-PEG5-CH2CH2N3 Basic information |
| Product Name: | HS-PEG5-CH2CH2N3 | | Synonyms: | HS-PEG5-CH2CH2N3;Azido-PEG5-Thiol;2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol;17-azido-3,6,9,12,15-pentaoxaheptadecane-1-thiol | | CAS: | 1449390-11-7 | | MF: | C12H25N3O5S | | MW: | 323.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1449390-11-7.mol |  |
| | HS-PEG5-CH2CH2N3 Chemical Properties |
| | HS-PEG5-CH2CH2N3 Usage And Synthesis |
| Uses | HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. HS-PEG5-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | Biological Activity | HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | HS-PEG5-CH2CH2N3 Preparation Products And Raw materials |
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