COX-2-IN-1
| 中文名称 | COX-2-IN-1 |
|---|---|
| 中文同义词 | 化合物 T10033;化合物COX-2-IN-1;化合物COX-2-IN-1,10 MM DMSO 溶液 |
| 英文名称 | 1-(4-Sulfamylphenyl)-3-trifluoromethyl-5-(7-chloroindol-3-yl)-2-pyrazoline |
| 英文同义词 | 1-(4-Sulfamylphenyl)-3-trifluoromethyl-5-(7-chloroindol-3-yl)-2-pyrazoline;4-(5-(7-chloro-1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide;COX-2-IN-1;Benzenesulfonamide, 4-[5-(7-chloro-1H-indol-3-yl)-4,5-dihydro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-;COX 2 IN 1,COX2IN1;COX-2-IN-1, 10 mM in DMSO |
| CAS号 | 787623-48-7 |
| 分子式 | C18H14ClF3N4O2S |
| 分子量 | 442.8425696 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 787623-48-7.mol |
| 结构式 |  |
COX-2-IN-1 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
COX-2-IN-1 是 一个强效的 COX-2 抑制剂，其 IC50 值为 3.9 μM。
|
COX-2 3.9 μM (IC 50 ) |
COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC 50 s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound.