133406-29-8
| 中文名称 | 133406-29-8 |
|---|---|
| 中文同义词 | 6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮;化合物ST034307;ST 034307,腺苷酸环化酶1(AC1)抑制剂;化合物ST034307,10 MM DMSO 溶液;抑制剂ST034307;ST034307 ,S0451;抑制剂ST034307 |
| 英文名称 | ST034307 |
| 英文同义词 | ST034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;ST034307;ST-034307;ST 034307;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;ST034307 >=98% (HPLC);Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase;ST034307, 10 mM in DMSO |
| CAS号 | 133406-29-8 |
| 分子式 | C10H4Cl4O2 |
| 分子量 | 297.95 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 133406-29-8.mol |
| 结构式 |  |
133406-29-8 性质
| 沸点 | 329.1±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.674±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 可溶于 DMSO（高达 30 mg/ml）或乙醇（高达 6 mg/ml） |
| 形态 | 固体 |
| 颜色 | 粘黄色 |
| 稳定性 | 自购买之日起，稳定期为 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月。 |
| InChI | 1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H |
| InChIKey | NTDHYMSVCBGQJF-UHFFFAOYSA-N |
| SMILES | ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O |
IC50: 2.3 μM (AC1)
ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca 2+ /calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.
ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E 50 ) value for analgesia of 0.28 μg in the mouse pain model.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S0451 | 133406-29-8 ST034307 | 133406-29-8 | 5mg | 4168.71元 |
| 2026/03/03 | S0451 | 133406-29-8 ST034307 | 133406-29-8 | 25mg | 12506.1元 |