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| | Bis-(N,N'-carboxyl-PEG4)-Cy5 Basic information |
| | Bis-(N,N'-carboxyl-PEG4)-Cy5 Chemical Properties |
| solubility | Soluble in Water, DMSO, DMF, DCM |
| | Bis-(N,N'-carboxyl-PEG4)-Cy5 Usage And Synthesis |
| Description | Bis-(N,N'-carboxyl-PEG4)-Cy5 is a PEG linker containing a cyanine dye with excitation/emmission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media. | | Uses | Bis-(N,N'-carboxyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bis-(N,N'-carboxyl-PEG4)-Cy5 Preparation Products And Raw materials |
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