t-Boc-N-Amido-PEG4-propargyl manufacturers
- Propargyl-PEG4-NHBoc
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- $0.00 / 5g
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2025-06-07
- CAS:1219810-90-8
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | t-Boc-N-Amido-PEG4-propargyl Basic information |
| Product Name: | t-Boc-N-Amido-PEG4-propargyl | | Synonyms: | t-Boc-N-Amido-PEG4-propargyl;Boc-N-Amido-PEG4-Alkyne;Propargyl-PEG4-NHBoc;tert-butyl (3，6，9，12-tetraoxapentadec-14-yn-1-yl)carbamate;tert-butylN-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)carbamate;Propargyl-PEG5-Boc Amine;Propargyl-PEG4-NHBoc/5,8,11,14-Tetraoxa-2-azaheptadec-16-ynoic acid, 1,1-dimethylethyl ester;5,8,11,14-Tetraoxa-2-azaheptadec-16-ynoic acid, 1,1-dimethylethyl ester | | CAS: | 1219810-90-8 | | MF: | C16H29NO6 | | MW: | 331.4 | | EINECS: | | | Product Categories: | SiChem | | Mol File: | 1219810-90-8.mol |  |
| | t-Boc-N-Amido-PEG4-propargyl Chemical Properties |
| Boiling point | 426.0±40.0 °C(Predicted) | | density | 1.054±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | pka | 12.23±0.46(Predicted) | | color | Colorless to light yellow |
| | t-Boc-N-Amido-PEG4-propargyl Usage And Synthesis |
| Description | t-Boc-N-Amido-PEG4-propargyl is a propargyl linker with one side protected by Boc group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc protected amine can be deprotected under mild acidic conditions. | | Uses | Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-N-Amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-N-Amido-PEG4-propargyl Preparation Products And Raw materials |
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