GLL398

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GLL398 Suppliers list
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
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Company Name: Cckinase, Inc.  
Tel: +1 (732)236-3202
Email: sales@cckinase.com
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 15850508050
Email: cindy.huang@synzest.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354;
Email: support@targetmol.com
GLL398 Basic information
Product Name:GLL398
Synonyms:CS-2735;GLL398
CAS:2077980-80-2
MF:C25H23BO4
MW:398.27
EINECS:
Product Categories:
Mol File:2077980-80-2.mol
GLL398 Structure
GLL398 Chemical Properties
Boiling point 602.7±65.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
pka4.46±0.10(Predicted)
Safety Information
MSDS Information
GLL398 Usage And Synthesis
UsesGLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC50=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.
References[1] Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368. DOI:10.1007/s10549-020-05558-w
GLL398 Preparation Products And Raw materials
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