5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene

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5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:AL-438；AL 438;AL438
CAS:239066-73-0
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: SYNTHENTA PVT LTD  
Tel: +91-7416102217 +91-7416102217
Email: gvpratapreddy@synthenta.com
Products Intro: Product Name:5-allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline
CAS:239066-73-0
Purity:97-99 % Package:1 kg,5 kg, 10 kg,25kg and 1 MT
Company Name: Shanghai Changyan Chem & Tech Co., Ltd.  
Tel: 021-20242659 18930833303
Email: sales@changyanchem.cn
Products Intro: Product Name:5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene
CAS:239066-73-0
Purity:95% HPLC Package:5KG;1KG;500G;100G;50G
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:AL-438
CAS:239066-73-0
Package:25mg
5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Basic information
Product Name:5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene
Synonyms:5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene;1H-[1]Benzopyrano[3,4-f]quinoline, 2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-(2-propen-1-yl)-;AL 438;AL438;AL-438;5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline
CAS:239066-73-0
MF:C23H25NO2
MW:347.45
EINECS:
Product Categories:
Mol File:239066-73-0.mol
5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Structure
5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Chemical Properties
Safety Information
MSDS Information
5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Usage And Synthesis
DescriptionAL-438 is a non-steroidal selective modulator for the glucocorticoid receptor (GR).
UsesAL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].
in vivo

AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats[2].

Animal Model:Male Sprague Dawley rats (carrageenan paw edema model)[2]
Dosage:1, 10, 100 mg/kg
Administration:P.o.
Result:Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay.
References[1] Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. DOI:10.1016/j.mce.2006.11.006
[2] Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. DOI:10.1210/me.2002-0355
5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Preparation Products And Raw materials
Tag:5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene(239066-73-0) Related Product Information