Mal-amido-PEG2-Val-Cit-PAB-PNP manufacturers
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| | Mal-amido-PEG2-Val-Cit-PAB-PNP Basic information |
| Product Name: | Mal-amido-PEG2-Val-Cit-PAB-PNP | | Synonyms: | Mal-amido-PEG2-Val-Cit-PAB-PNP;4-((2S,5S)-19-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-isopropyl-4,7,17-trioxo-2-(3-ureidopropyl)-10,13-dioxa-3,6,16-triazanonadecanamido)benzyl (4-nitrophenyl) carbonate | | CAS: | 2112738-13-1 | | MF: | C39H50N8O14 | | MW: | 854.86 | | EINECS: | | | Product Categories: | ADC LINKER | | Mol File: | 2112738-13-1.mol |  |
| | Mal-amido-PEG2-Val-Cit-PAB-PNP Chemical Properties |
| storage temp. | Storage temp. -20°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Solid | | color | White to off-white |
| | Mal-amido-PEG2-Val-Cit-PAB-PNP Usage And Synthesis |
| Description | Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable ADC linker containing a maleimide group that can be reacted with thiol containing molecules.. The Val-Cit will specifically be cleaved by Cathepsin B.PNP can be substituted by nucleophiles. | | Biological Activity | Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable ADC linker containing 2 units of PEG, which can be used to synthesize antibody drug conjugates (ADCs). | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | |
| | Mal-amido-PEG2-Val-Cit-PAB-PNP Preparation Products And Raw materials |
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