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Selective PI3Kδ Inhibitor 1 manufacturers
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| | Selective PI3Kδ Inhibitor 1 Basic information |
| Product Name: | Selective PI3Kδ Inhibitor 1 | | Synonyms: | Selective PI3Kδ Inhibitor 1;SelectivePI3KδInhibitor1(compound7n);PI3Kδ-IN-7n;compound 7n;SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N;PI3K delta-IN-7n;Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-;SelectivePI3KδInhibitor1 | | CAS: | 2088525-31-7 | | MF: | C23H20FN7O | | MW: | 429.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2088525-31-7.mol |  |
| | Selective PI3Kδ Inhibitor 1 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 43 mg/mL (100.13 mM);Ethanol: Insoluble | | form | Solid | | color | Off-white to gray | | Water Solubility | Water: Insoluble |
| | Selective PI3Kδ Inhibitor 1 Usage And Synthesis |
| Uses | PI3Kδ-IN-5 (compound 7n) is a highly potent and selective inhibitor of PI3Kδ with an IC50 of 0.9 nM[1]. | | Biological Activity | Selective PI3Kδ Inhibitor 1 (compound 7n) is a PI3Kδ inhibitor with IC50 of 0.9 nM for PI3Kδ, which is more than 1000-fold selective for other class I PI3K isoforms. The IC50 values of it for PI3Kα/γ/β were 3670, 1460, and 21300 nM, respectively. | | in vivo | Selective PI3Kδ Inhibitor 1 has favorable pharmacokinetic profile: good bioavailability and moderate in vivo half-life. In rats, its oral bioavailability was 41%; after intravenous injection, Vss, T 1/2 and CL were 2.8 L/kg, 3.4 h and 12 mL/min/kg, respectively . | | target | | Target | Value | PI3Kδ
(Cell-free assay) | 0.9 nM |
| | References | [1] Terstiege I, et al. Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors. Bioorg Med Chem Lett. 2017;27(3):679-687. DOI:10.1016/j.bmcl.2016.11.004 |
| | Selective PI3Kδ Inhibitor 1 Preparation Products And Raw materials |
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