PRION PROTEIN (106-126) (HUMAN)
| 中文名称 | PRION PROTEIN (106-126) (HUMAN) |
|---|---|
| 中文同义词 | 106-126-朊蛋白;PRION片段多肽;人源朊病毒肽(106-126) |
| 英文名称 | H-LYS-THR-ASN-MET-LYS-HIS-MET-ALA-GLY-ALA-ALA-ALA-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY-OH |
| 英文同义词 | H-KTNMKHMAGAAAAGAVVGGLG-OH;H-KTNMKHMAGAAAAGAWGGLG-OH;H-LYS-THR-ASN-MET-LYS-HIS-MET-ALA-GLY-ALA-ALA-ALA-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY-OH;KTNMKHMAGAAAAGAVVGGLG;Prion protein fragment 106-126 human, ≥90% (HPLC);LYS-THR-ASN-MET-LYS-HIS-MET-ALA-GLY-ALA-ALA-ALA-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY;PRION PROTEIN FRAGMENT 106-126 HUMAN;PRION PEPTIDE (106-126), HUMAN |
| CAS号 | 148439-49-0 |
| 分子式 | C80H138N26O24S2 |
| 分子量 | 1912.25 |
| EINECS号 | |
| 相关类别 | 多肽;生化试剂;其他生化试剂;标准品;目录多肽;Peptide |
| Mol文件 | 148439-49-0.mol |
| 结构式 |  |
PRION PROTEIN (106-126) (HUMAN) 性质
| 沸点 | 2216.1±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.283±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 酸度系数(pKa) | 3.33±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 1 mg/ml in water |
| 序列 | Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly |
| InChIKey | XPZWWTIIKSODDO-MBNDGZRNSA-N |
PrP (106-126) (100 μM) induces mTOR phosphorylation over time in N2a cells. PrP (106-126)-treated cells show significantly increased ROS production in comparison with that of PBS-treated control cells. Knockdown of PRAS40 enhances PrP (106-126)-induced apoptosis. PRAS40 alleviates PrP (106-126)-induced neuronal apoptosis via mTOR-AKT activation. PrP (106-126) interacts selectively with porcine brain endothelial cells (PBEC) via their luminal side, and causes cumulative cell death, as shown by lactate dehydrogenase release, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, Caspase 3 induction and direct cell counting. In addition, PrP (106-126), but not its corresponding scrambled peptide, produces a 50% reduction of the trans-endothelial electrical resistance, while the PBEC maintained confluency.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN) PrP 106-126 | 148439-49-0 | 1mg | 800元 |
| 2025/12/22 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN) PrP 106-126 | 148439-49-0 | 5mg | 2000元 |