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ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

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Products Intro: Product Name:GBR 12935 dihydrochloride
CAS:67469-81-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
CAS:67469-81-2
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Products Intro: Product Name:GBR 12935 dihydrochloride
CAS:67469-81-2
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Products Intro: Product Name:GBR 12935 dihydrochloride
CAS:67469-81-2
Purity:99% Package:5KG;1KG Remarks:GBR 12935 dihydrochloride
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Products Intro: Product Name:GBR 12935 HCl
CAS:67469-81-2
Purity:98% Package:10mg Remarks:V2045

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE manufacturers
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Basic information
Product Name:1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
Synonyms:GBR 12935 dihydrochloride, >=98%;GBR 12935 (hydrochloride);GBR 12935 DIHYDROCHLORIDE;1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE;GBR-12935 2HCL;GBR 12935 HCl;1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride;Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2)
CAS:67469-81-2
MF:C28H35ClN2O
MW:451.05
EINECS:
Product Categories:Inhibitors
Mol File:67469-81-2.mol
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Structure
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemical Properties
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility H2O: 20 mg/mL with warming
form powder
color white
Water Solubility H2O: 20mg/mL (with warming)
InChIInChI=1S/C28H34N2O.ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;/h1-9,11-12,14-17,28H,10,13,18-24H2;1H
InChIKeyYMGXBGVMAOTRFZ-UHFFFAOYSA-N
SMILESC(C1C=CC=CC=1)(C1C=CC=CC=1)OCCN1CCN(CCCC2C=CC=CC=2)CC1.Cl
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Usage And Synthesis
UsesA very potent and selective inhibitor of dopamine uptake
DefinitionChEBI: A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal memb anes).
Biochem/physiol ActionsGBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.
in vivo

GBR 12935 dihydrochloride (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections[3].

Animal Model:Adult male DBA/2J and C57BL/6J mice (22-30 g)[3]
Dosage:1.0, 3.2, 10, 32 mg/kg
Administration:Repeat injection; for 7 days
Result:Elevated locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice.
No stereotypy was induced by an eighth day challenge of 10 mg/kg GBR 12935 dihydrochloride in mice pretreated with seven dally injections of either 32 mg/kg cocaine or saline.
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials
Tag:1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE(67469-81-2) Related Product Information
Diphenhydramine 1-(2-ETHOXYETHYL)PIPERAZINE 1-(3-PHENYLPROPYL)PIPERAZINE PIPERAZINE DIHYDROCHLORIDE Diphenhydramine Hydrochloride 1-(2-BENZYLOXY-ETHYL)-PIPERAZINE 2-(DIPHENYLMETHOXY)-N-METHYLETHYLAMINE Vanoxerine dihydrochloride 1-(2-Methoxyethyl)piperazine 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
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