托美丁钠(二水)
| 中文名称 | 托美丁钠(二水) |
|---|---|
| 中文同义词 | 托美丁钠二水合物;1-甲基-5-(P-甲苯酰基)吡咯-2-乙酸钠盐;托美丁钠(二水);2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水);托尔米汀钠;灭定钠;托美丁钠 USP标准品;化合物 T2550L |
| 英文名称 | Sodium tolmetin dihydrate |
| 英文同义词 | sodiumtolmetindihydrate;tolmetinsodiumdihydrate;1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium-potassium salt dihydrate;TOLMELINSODIUM;Tolmetinsodiumsaltdihydratecrystalline;1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate;1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate;5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate |
| CAS号 | 64490-92-2 |
| 分子式 | C15H14NO3.Na.2H2O |
| 分子量 | 315.3 |
| EINECS号 | 626-708-5 |
| 相关类别 | 医药中间体;化工中间体;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;BETAGAN;API intermediates |
| Mol文件 | 64490-92-2.mol |
| 结构式 |  |
托美丁钠(二水) 性质
| 熔点 | 155-157 (dec.) |
|---|---|
| 储存条件 | -20°C Freezer |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble in water |
| InChI | InChI=1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1 |
| InChIKey | QQILXENAYPUNEA-UHFFFAOYSA-M |
| SMILES | C1(=CC=C(CC([O-])=O)N1C)C(=O)C1C=CC(C)=CC=1.O.O.[Na+] |
| CAS 数据库 | 64490-92-2(CAS DataBase Reference) |
|
Human COX-1 0.35 μM (IC 50 ) |
Human COX-2 0.82 μM (IC 50 ) |
Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth.
Tolmetin sodium dihydrate (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
安全信息
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S4360 | 托美丁钠(二水) Tolmetin Sodium | 64490-92-2 | 25mg | 795.3元 |
| 2025/12/22 | HY-B1489 | 托美丁钠(二水) Tolmetin sodium dihydrate | 64490-92-2 | 100mg | 500元 |