N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide

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N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide Suppliers list
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Tel: 15865264761
Email: 486064515@qq.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide Basic information
Product Name:N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide
Synonyms:N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide;2-Furancarboxamide, N-(2-phenyl-5-benzoxazolyl)-;Progranulin modulator-3
CAS:371116-39-1
MF:C18H12N2O3
MW:304.3
EINECS:
Product Categories:
Mol File:371116-39-1.mol
N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide Structure
N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide Chemical Properties
Boiling point 385.7±17.0 °C(Predicted)
density 1.343±0.06 g/cm3(Predicted)
form Solid
pka11.35±0.43(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide Usage And Synthesis
UsesProgranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research[1].
in vivo

Progranulin modulator-3 (10 mg/kg, i.p., 24h) shows a half life of 41 min and Cmaxs of 1498 ng/mL and 6246 ng/g in mice plasma and brain, respectively, and increases PGRN protein levels in Grn+/ mouse brains[1].

References[1] Tesla R, et al. Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nat Commun. 2024 Jul 20;15(1):6125. DOI:10.1038/s41467-024-50076-8
N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide Preparation Products And Raw materials
Tag:N-(2-phenyl-1,3-benzoxazol-5-yl)furan-2-carboxamide(371116-39-1) Related Product Information
Benzamide, N-(2-methyl-6-benzoxazolyl)- (9CI) 3-bromo-N-(2-phenyl-1,3-benzoxazol-5-yl)benzamide 3,4-dimethoxy-N-[2-(4-methoxyphenyl)-1,3-benzoxazol-5-yl]benzamide 3-chloro-N-[2-(5-chloronaphthalen-1-yl)-1,3-benzoxazol-5-yl]benzamide Benzamide, 3-methyl-N-[3-[5-(1-methylethyl)-2-benzoxazolyl]phenyl]- (9CI) 2-Benzofurancarboxamide, N-[4-[[[4-(2-benzoxazolyl)phenyl]amino]carbonyl]phenyl]-5-methoxy-3-methyl-