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| | 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Basic information |
| Product Name: | 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid | | Synonyms: | 6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID;6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-16-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid-carboxylic acid;6-Hydroxy-1,2,3,4-tetrahydro-sioquinoline-1-carboxylicacid;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxcarboxylicacid;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-caeboxylic acid;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carbox;1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6-hydroxy-;6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid, CAS 91523-50-1 | | CAS: | 91523-50-1 | | MF: | C10H11NO3 | | MW: | 193.2 | | EINECS: | | | Product Categories: | | | Mol File: | 91523-50-1.mol |  |
| | 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Chemical Properties |
| Boiling point | 458.1±45.0 °C(Predicted) | | density | 1.351±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 2.05±0.20(Predicted) |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Usage And Synthesis |
| Uses | 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic Acid is useful chemical in the studying of proline containing peptides as caspase-2 inhibitors. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 27, p. 1321, 1984 DOI: 10.1021/jm00376a017 | | Synthesis | GENERAL PROCEDURE: A solution of 2-oxoacetic acid monohydrate (2.0 g, 22 mmol) in ethanol (10 mL) was added slowly and dropwise to a denatured ethanol (70 mL) solution of 3-hydroxyphenylethylamine hydrochloride (3.08 g, 22.5 mmol) at 4 °C. Immediately after the dropwise addition, a white precipitate was observed to be generated. The ice bath was removed and the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the white solid product 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (3.1 g, 73% yield) was collected by filtration. The product was analyzed by LC/MS (electrospray, positive ion mode) and showed m/z 194 ([M+H]+). | | References | [1] Journal of Medicinal Chemistry, 1984, vol. 27, # 10, p. 1321 - 1325
[2] Patent: US6649606, 2003, B1. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 47 - 50
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 7, p. 1799 - 1802 |
| | 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid Preparation Products And Raw materials |
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