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1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

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Company Name: Shaanxi Dideu Medichem Co. Ltd
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Products Intro: Product Name:1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
CAS:1127-74-8
Purity:98.0% Package:1KG;0.1USD
Company Name: ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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Products Intro: Product Name:1,2,3,4-Tetrahydrobenzo[b]azepin-5-one
CAS:1127-74-8
Purity:99%min Package:100kg;1.10;USD|25kg;3.30;USD|1kg;9.90;USD
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Products Intro: Product Name:1,2,3,4-Tetrahydrobenzoazepine-5-one
CAS:1127-74-8
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
CAS:1127-74-8
Purity:99% Package:25KG;5KG;1KG
Company Name: career henan chemical co
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Products Intro: Product Name:1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
CAS:1127-74-8
Purity:99% Package:1KG;1USD

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one manufacturers
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Basic information
Product Name:1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
Synonyms:1,2,3,4-tetrahydrobenzo[b]azepin-5-tone;5-oxo-2,3,4,5-tetrahydro-1H-benzazepine;5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-;1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;1,2,3,4-Tetrahydrobenzoazepine-5-one;1,2,3,4-Tetrahydrobenzazepine-5-one, 97%;1,2,3,4-Tetrahydro-5H-1-benzazepin-5-one;3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
CAS:1127-74-8
MF:C10H11NO
MW:161.2
EINECS:672-555-2
Product Categories:Building Blocks/Intermediates;pharmacetical
Mol File:1127-74-8.mol
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Structure
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Chemical Properties
Boiling point 314.6±12.0 °C(Predicted)
density 1.100±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka3.05±0.20(Predicted)
form Powder
color White to light green
InChIInChI=1S/C10H11NO/c12-10-6-3-7-11-9-5-2-1-4-8(9)10/h1-2,4-5,11H,3,6-7H2
InChIKeyNKRKBYFBKLDCFB-UHFFFAOYSA-N
SMILESN1C2=CC=CC=C2C(=O)CCC1
CAS DataBase Reference1127-74-8(CAS DataBase Reference)
Safety Information
HazardClass IRRITANT
HS Code 2933998090
MSDS Information
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Usage And Synthesis
Synthesis Polyphosphoric acid (25g) was heated at 100°C under nitrogen until it could be stirred. 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydro-benzo[b]azepin-5-one (2.6g, 8.2 6mmol) was added portion-wise and the reaction mixture was heated at 100°C for 1.5h. It was poured into ice and basified with 2M NaOH(aq). The aqueous layer was extracted twice with dichloromethane. The organic extracts were combined, washed with brine, dried and reduced in vacuo. The residue was purified by flash chromatography on silica gel (eluant; 40percent EtOAc: 60percent hexane) to yield 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one (1.05g, 79percent).
References[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 19, p. 8670 - 8692
[2] Patent: WO2006/21213, 2006, A2. Location in patent: Page/Page column 34
[3] Patent: WO2005/37796, 2005, A1. Location in patent: Page/Page column 39
[4] Journal of Organic Chemistry, 2016, vol. 81, # 8, p. 3136 - 3148
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Preparation Products And Raw materials
Raw materials1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
Preparation Products2,3,4,5-Tetrahydro-1H-benzo[b]azepine
Tag:1,2,3,4-Tetrahydro-benzo[b]azepin-5-one(1127-74-8) Related Product Information
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